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崔晓杰

【来源: | 发布日期:2018-11-23 】


崔晓杰

汉族,讲师

教育经历:2015.6-2017.7法国巴黎居里研究所(Institut Curie)博士后

2014.7-2015.5北京大学化学与分子工程新2最新备用288880(袁谷教授组)研究助理

2009.9-2014.7北京大学化学与分子工程新2最新备用288880(化学生物学)博士

2005.9-2009.7山东大学化学与化工新2最新备用288880(化学基地班) 学士

通信地址:北京市海淀区中关村南大街27号 新2最新备用288880

邮编:100081

电子邮箱:xiaojiecui@muc.edu.cn

讲授课程

有机化学,有机化学实验

主要研究内容

鸟嘌呤四聚体(G-四链体)是一种特殊的核酸高级结构,其存在与原癌基因的转录、翻译,染色体端粒的稳定性,以及神经细胞的活性等密切相关,我的研究方向主要为采用多种生化分析方法探测合成及天然小分子化合物与G-四链体的选择性识别,从而为相关疾病的调控提供潜在手段。

代表作

1.Aurèle Piazza#,Xiaojie Cui#, Michael Adrian, Frédéric Samazan, BrahimHeddi, Anh Tu?n Phan* and Alain Nicolas*, “Non-Canonical G-quadruplexes Cause the hCEB1 Minisatellite Instability inSaccharomyces cerevisiae”, #co-first author,eLife,2017, 6, e26884.

2.Xiaojie Cui, Qiang Zhang, Han Chen, Jiang Zhou, and Gu Yuan*, “ESI Mass Spectrometric Exploration of Selective Recognition of G-Quadruplex in c-myb Oncogene Promoter Using a Novel Flexible Cyclic Polyamide”,J. Am. Soc. Mass Spectrom.,2014, 25, 684.

3.Xiaojie Cui, Sen Lin, Jiang Zhou and Gu Yuan*, “Investigation of non-covalent interaction

of natural flexible cyclic molecules with telomeric RNA G-quadruplexes by electrospray ionization mass spectrometry”,Rapid Commun. Mass Spectrom.,2012, 26 , 1803.

4.Xiaojie Cui, Sen Lin and Gu Yuan*, “Spectroscopic probing of recognition of the G-quadruplex in c-kit promoter by small-molecule natural products”,Int. J. Biol. Macromol.,2012, 50, 996.

5.Xiaojie CuiandGu Yuan*, “Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry”,J. Mass Spectrom.,2011, 46, 849.

6.Qiang Zhang,Xiaojie Cui, Sen Lin, Jiang Zhou, and Gu Yuan*, “Convenient Method for the Synthesis of a Flexible Cyclic Polyamide for Selective Targeting of c-myb G-quadruplex DNA”,Org. Lett.,2012, 14, 6126.

7.Han Chen, Haitao Long,Xiaojie Cui, Jiang Zhou, Ming Xu and Gu Yuan*, “Exploring the Formation and Recognition of an Important G-Quadruplex in a HIF1-alpha Promoter and Its Transcriptional Inhibition by a Benzo-c-phenanthridine Derivative”,J. Am. Chem. Soc.,2014, 136, 258.

8.Sen Lin, HuipingGu, Ming Xu,Xiaojie Cui, Youyi Zhang, Wei Gao and Gu Yuan, “The Formation and Stabilization of a Novel G-Quadruplex in the 5 '-Flanking Region of the Relaxin Gene”,Plos One,2012, 7, e31201.

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